Cherie DeVille was born on August 30, 1978 in Durham, North Carolina, but grew up in Washington, DC and Cape Cod, Massachusetts. She is of French-Canadian descent. Cherie had an active childhood: she rode horses, she was a dancer, she played in the school band and she was an animator for several years.

When DeVille was sixteen, he was a lifeguard and was also on the swim team. Before beginning her pornographic career, Cherie worked as a physiotherapist. Cherie was interacting with girls from the sixth grade but lost her virginity to a boy when she was 17 years old.